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ea0084ps3-13-120 | Pregnancy & Iodine | ETA2022

The impact of thyroid function on neonatal outcome in women with polycystic ovary syndrome treated with metformin or placebo during pregnancy

Trouva Anastasia , Alvarsson Michael , Calissendorff Jan , Olav AEsvold Bjorn , Linden Hirschberg Angelica , Vanky Eszter

Objectives: Polycystic ovary syndrome (PCOS) and thyroid disorders have separately been linked to adverse pregnancy and neonatal outcomes. Even small variations in thyroid function within the normal range may influence fetal growth. Previous data have shown that metformin-treatment of pregnant women with PCOS reduced late miscarriages and preterm births, and resulted in less decrease of fT4 compared to placebo. Moreover, metformin exposure in utero altered the offspring anthro...

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ea0092op-08-02 | Oral Session 8: Hypothyrodism / Nodules | ETA2023

Individuals on levothyroxine have higher hads anxiety and depression scores than the general population and this is exacerbated by the THR92ALA substitution in DIO2, particularly at higher doses

Taylor Peter , Haug Eirin , Hanna Stephanie , Heald Adrian , Stedman Mike , Premawardhana Lakdasa , Okosieme Onyebuchi , Olav AEsvold Bjorn , Dayan Colin

Context: Approximately 15% of people with hypothyroidism remain symptomatic despite treatment. The Thr92Ala substitution in DIO2, may influence T3 tissue levels.Methods: We assessed HADS anxiety and depression scores in HUNT2 in 50,901 individuals (6,687 homozygous for Thr92Ala) of whom 1,480 had a history of levothyroxine use (180 homozygous for Thr92Ala). Anxiety and depression caseness (score>=8) by levothyroxine and Thr92Ala status was a...

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Endocrine Abstracts

The impact of thyroid function on neonatal outcome in women with polycystic ovary syndrome treated with metformin or placebo during pregnancy

Individuals on levothyroxine have higher hads anxiety and depression scores than the general population and this is exacerbated by the THR92ALA substitution in DIO2, particularly at higher doses

BiosciAbstracts